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Trials designed to inform clinical practice in the real world are known as pragmatic trials. They are often described as focusing on practical aspects of study design that include the recruitment process and consent, adhering and the use of standard equipment.
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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for pragmatic trials to be reliable and lessen the chance of bias is also essential. However, 프라그마틱 슬롯 팁 can result in issues with the design of the trial.
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The purpose of pragmatic trials is to replicate real-life situations and achieve maximum validity externally. They are usually requested by practitioners and policymakers in order to inform their decisions. They can be used to determine the causal relationship between an intervention and its effects. However, they should not be used to replace explanation studies.
The pragmatism idea is controversial, and there are questions regarding whether pragmatic trials could be used to replace explanation tests or if they are an addition to them. Schwartz and Lellouch1 suggested an distinction between explanation-based studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study which includes recruitment, design, implementation of the intervention and its follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, which are shown in red in Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatic thinking. It is important to note, however, that the majority of these studies were conducted in primary-care settings.